Anabolic steroid. White or white crystalline powder with a yellow tinge. Very slightly soluble in water, slightly soluble in ether, easily soluble in ethyl alcohol and chloroform.
Pharmacological action - anabolic, hematopoietic.
Penetrating into the cell nucleus, it activates the genetic apparatus of the cell, which leads to increased synthesis of DNA, RNA and structural proteins, activation of enzymes of the tissue respiratory chain and enhanced tissue respiration, oxidative phosphorylation, ATP synthesis and accumulation of macroergs inside the cell. Stimulates anabolic and suppresses catabolic processes caused by glucocorticoids. Leads to an increase in muscle mass, reduced fat deposits and a negative nitrogen balance. Hematopoietic action is associated with increased synthesis of erythropoietin. The antiallergic effect is due to an increase in the concentration of C1 of the complement fraction of the inhibitor and a decrease in the content of C2 and C4 fractions of complement. Androgenic activity (low) may contribute to the development of secondary sexual characteristics of the male type.
Quickly and completely absorbed from the gastrointestinal tract, low bioavailability is due to the effect of "first pass" through the liver. It is 90% bound to specific carrier globulins in the blood. It undergoes final biotransformation in the liver with the formation of inactive metabolites. Excreted by the kidneys. Duration of action - up to 14 hours.